Apolipoprotein E, Especially Apolipoprotein E4, Increases the Oligomerization of Amyloid Peptide
نویسندگان
چکیده
منابع مشابه
Neurobiology of Disease Apolipoprotein E, Especially Apolipoprotein E4, Increases the Oligomerization of Amyloid Peptide
Tadafumi Hashimoto,1 Alberto Serrano-Pozo,1 Yukiko Hori,1 Kenneth W. Adams,1 Shuko Takeda,1 Adrian Olaf Banerji,1 Akinori Mitani,1 Daniel Joyner,1 Diana H. Thyssen,1 Brian J. Bacskai,1 Matthew P. Frosch,1 Tara L. Spires-Jones,1 Mary Beth Finn,2 David M. Holtzman,2 and Bradley T. Hyman1 1Department of Neurology, Alzheimer’s Disease Research Unit, Massachusetts General Hospital, Charlestown, Mass...
متن کاملApolipoprotein E, especially apolipoprotein E4, increases the oligomerization of amyloid β peptide.
Alzheimer's disease (AD) is the most common progressive neurodegenerative disorder causing dementia. Massive deposition of amyloid β peptide (Aβ) as senile plaques in the brain is the pathological hallmark of AD, but oligomeric, soluble forms of Aβ have been implicated as the synaptotoxic component. The apolipoprotein E ε 4 (apoE ε4) allele is known to be a genetic risk factor for developing AD...
متن کاملMelatonin reverses the profibrillogenic activity of apolipoprotein E4 on the Alzheimer amyloid Abeta peptide.
Inheritance of apoE4 is a strong risk factor for the development of late-onset sporadic Alzheimer's disease (AD). Several lines of evidence suggest that apoE4 binds to the Alzheimer Abeta protein and, under certain experimental conditions, promotes formation of beta-sheet structures and amyloid fibrils. Deposition of amyloid fibrils is a critical step in the development of AD. We report here th...
متن کاملAssociation of apolipoprotein E4 and haplotypes of the apolipoprotein E gene with lobar intracerebral hemorrhage.
BACKGROUND AND PURPOSE Conflicting reports in the literature exist with regard to the association of apolipoprotein E (apo E) alleles and lobar intracerebral hemorrhage (ICH). We genotyped 12 single-nucleotide polymorphisms in the 5' upstream regulatory, exonic, and intronic regions of the apo E gene and performed genotype and haplotype association analyses. METHODS We prospectively enrolled ...
متن کاملAmyloid mediates the association of apolipoprotein E e4 allele to cognitive function in older people.
BACKGROUND The neurobiological changes underlying the association of the apolipoprotein E (APOE) e4 allele with level of cognition are poorly understood. OBJECTIVE To test the hypothesis that amyloid load can account for (mediate) the association of the APOE e4 allele with level of cognition assessed proximate to death. METHODS There were 44 subjects with clinically diagnosed Alzheimer's di...
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ژورنال
عنوان ژورنال: Journal of Neuroscience
سال: 2012
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.1542-12.2012